Graduate School in Physics and Astrophysics ------------------------------------------- ANNUAL REPORT ------------------------------------------- Fill with a text editor (without TAB or formatting) Repeat fields for each course as necessary. ------------------------------------------- name: Mohammad VARASTEH ANVAR email: varasteh@to.infn.it ciclo: XXVIII year completed (1,2 or 3): 3 supervisor: Prof. Vincenzo Monaco ------------------------------------------- GRADUATE SCHOOL COURSES (only completed courses, with examination passed in the year) 4h=1CFU code: 09 title: Hands-on Fitting and Statistical Tools for Data Analysis teacher: Prof. Marco Pelliccioni hours: 16 [4 credits] ------------------------------------------- SUMMER SCHOOLS, INTERNATIONAL SCHOOLS (only those attended in the current year) title: International school of ESTRO - Imaging for Physicists place: Leiden, the Netherlands webpage: http://www.estro.org/school/items---list-courses-school-main-pages/2015-leiden---imaging-for-physicists days: Full Week (start on 13 - end on 17 September) talk or poster (Y/N): Y (talk) ------------------------------------------- CONFERENCES, WORKSHOP (only those attended in the current year) title: ENLIGHT 2015 place: Krakow, Poland webpage: http://enlight.web.cern.ch/features/enlight-annual-meeting-2015-krakow-poland days: 3 talk or poster (Y/N): Y (talk) title: AAPM 2015 place: Anaheim, CA, USA webpage: www.aapm.org/meetings/2015AM/ days: 5 talk or poster (Y/N): Y (poster) title: Tutorial PlanKIT - Germano Russo, Isee place: Dipartimento di Fisica, Via Pietro Giuria 1 webpage: http://www.to.infn.it/ days: 1 talk or poster (Y/N): N title: RDH - Marco Durante, INFN place: Dipartimento di Fisica, Via Pietro Giuria 1 webpage: http://www.to.infn.it/ days: 1 talk or poster (Y/N): N ------------------------------------------- VISITS AND STAGES (only those done in the current year) institution: Candiolo Cancer Institute, Fondazione IRCCS place: Turin, Italy starting date: 05/08/2015 days: 3 institution: CERN place: Geneva, Switzerland starting date: 25/08/2015 days: 3 institution: IFJ PAN (Polish National Centre for Hadrontherapy) place: Krakow, Poland starting date: 21/09/2015 days: 1 --------------------------------------------------- Research activity/Publications in the current year (max characters 2500) “New tools for Quality Assurance and online dose verification in charged particle therapy” is the title of my PhD thesis and cautiously it is twofold. At first I have been responsible for developing an accurate and fast approach for QA checks of carbon ion and proton beams using the 2D MatriXX detector [1]. The MatriXX device, developed by INFN and University of Torino, engineered and commercialized by IBA (Be), is a pixel-segmented ionization chamber array for real-time QA of conventional beams. Most of the systems in use for scanned ion beam QA are based on single or arrays of ionization chambers and films, which are certainly precise but suffer for lengthy procedures. Therefore the goal was to investigate the possibility of using the 2D MatriXX detector interfaced with the OmniPro-I'mRT software, to check three main objectives: beam position measurement, beam width determination, and field dose uniformity and flatness. In current year I have implemented the final analyses using programs developed in-house with NI LabVIEW. Using Monte Carlo simulation to apply corrections, the results showed quite satisfactory agreement with those from GAFCHROMIC film. Recently we submitted a paper on this work to the peer-reviewed journal of “PhysicaMedica”. In the second part of thesis I have been involved in the INFN project of RIDOS (Real-Time Ion Dose Planning and Delivery System) which is aimed to integrate a very fast Forward Planning system, based on GPU, in a Dose Delivery System able to evaluate and compare planned and delivered dose, on-line, spill by spill [2]. By porting an exist TPS code to CUDA in order to be run on GPU, gain factor equal to 700 for a number of 800000 points (corresponds to a plan with 1248 spots (rays) and 39 slices (E)) is achieved. To take into account the patient movements, registration methods are used to transform the 3D-CT images corresponding to different respiratory phases of a 4D-CT to each other, on a voxel-by-voxel basis. This will allow modelling the anatomy and accumulating the dose distribution of all phases to the reference phase. In this project I was in charge of designing and validating the proper non-rigid image registration algorithm. Using the Insight Toolkit (ITK) I have studied, optimized and used algorithms to perform the lung 4D-CT deformable registration aiming to find transform parameters which describe the mapping between the reference phase and all other moving phases of 4D-CT. For quantitative registration validation I have used a method based on known deformation fields and the qualitative validation is done using image analysis software such as VV 4D-slicer, MIPAV and ImageJ. Currently I am writing my thesis. Results have been presented in several conferences, meetings and journal: [1] M. Varasteh et.al, Use of the 2D MatriXX Detector for Measuring Scanned Ion Beam Parameters, MEDICAL PHYSICS 42(6):3516 • JUNE 2015 [2] S. Giordanengo, A Attili, A Vignati, M Varasteh et.al, On-line forward planning integrated in a dose delivery system for scanning ion beams, PTCOG 54, San Diego, California, USA [3] M. Varasteh Anvar et.al, Quality assurance of carbon ion and proton beams: a feasibility study for using the 2D MatriXX detector, to be submitted to the journal of PhysicaMedica [4] R. Cirio, F. Fausti, L. Fanola Guarachi, S. Giordanengo, F. Marchetto, G. Mazza, V. Monaco, R. Sacchi, E. Talpacci, M. Varasteh Anvar, A. Vignati, A simple method to increase the current range of the TERA chip in charged particle therapy applications, Nuclear Inst. and Methods in Physics Research, A 798 (2015) 107–110 [5] L. Fanola Guarachi, R. Sacchi, S. Giordanengo, F. Marchetto, E. Talpacci, V. Monaco, M. Stasi, M. Donetti, A. Vignati, M. Varasteh Anvar, R. Cirio, Multi- Gap Ionization Chamber for High-Flux Charged Particla Beams, Med Phys. 2015 Jun;42(6):3727 [6] S. Giordanengo, A. Attili, M. Varasteh et.al, A ON-LINE GPU-BASED FORWARD PLANNING INTEGRATED INTO A DOSE DELIVERY SYSTEM FOR ADAPTIVE HADRONTHERAPY, ENLIGHT 2015